MICHAEL ADDITION OF BENZOYLACETONITRILE TO CHIRAL ALPHA-CYANOACRYLATES DERIVED FROM ENANTIOMERICALLY PURE ALPHA-HYDROXYALDEHYDES - SYNTHESIS OF 3-ALKOXYCARBONYL-4-ALKYL-2-AMINO-5-CYANO-6-PHENYL-4H-PYRAN

摘要

We describe the Michael addition of benzoylacetonitrile to alpha-cyanoacrylates 4a-c and 5a obtained from readily available chiral alpha-hydroxyaldehydes 1a-c. The resulting polyfunctionalized 4-alkyl-2-amino-4H-pyrans 6a-c, 7a have been obtained in good yield and moderate diastereoselectivity. [References: 13]