A short and convenient synthesis and evaluation of the antiinfective properties of indoloquinoline alkaloids: 10H-Indolo[3,2-b]quinoline and 7H-indolo[2,3-c]quinolines

摘要

10H-Indolo[3,2-b]quinoline and 7H-indolo[2,3-c]quinoline have been synthesized in two steps using a modified approach to our previous reported method. Starting from commercially available 3-aminoquinoline and phenylboronic acid, the first step involved a copper acetate-catalyzed coupling reaction and the second utilized a palladium acetate-catalyzed intramolecular arylation reaction in the presence of trifluoroacetic acid as solvent. The anti-infective activity of a selected number of the compounds was also evaluated.