Delta(2)-isoxazolines from beta,gamma-unsaturated oximes

摘要

3,5-Disubstituted Delta(2)-isoxazolines can be prepared using the palladium-mediated nucleometalation/methoxycarbonylation of beta,gamma-unsaturated oximes. This novel route to this class of compounds is tolerant of a wide variety of functionality in the starting material, and provides a rapid route to highly functionalized isoxazolines.