The preparation of benzoisothiazolo[1,2-b] [1,2]isoquinolin-11-one1,1-dioxides from dilithiated ortho-toluic acids and lithiated methyl 2-(aminosulfonyl)benzoate

摘要

Select dilithiated ortho-toluic acids were prepared in excess lithium diisopropylamide and condensed with methyl 2-(aminosulfonyl)benzoate followed by a twofold cyclization of intermediates to afford benzoisothiazolo [1,2-b] [1,2]isoquinolin-11-one- 1, 1-dioxides, a new fused-ring heterocyclic system.