Synthesis of Certain 5-Substituted Thieno[2,3-b]thiophene-2-sulfonamides and Thieno[2,3-b]thiophene-2-sulfonamide 6,6-Dioxides

摘要

A series of the title compounds were prepared for evaluation as inhibitors of carbonic anhydrase II. Oxidation of 5-substituted thieno[2,3-b]thiophene-2-sulfonamides provided the first examples of thiophene[2,3-b]thiophene-2-sulfonamide 6,6-dioxides. These cyclic vinyl sulfones readily underwent addition to give predominately that 4,5-cis addition product.