Hydrobromic Acid-Dimethyl Sulfoxide Reagent for Dealkylation of 5,10-Dialkyl-5,10-dihydrophenazines: Synthesis of 10-Alkyl-2(10H)-phenazinones

摘要

By the reaction of 5,10-dialkyl-substituted 5,10-dihydrophenazine with hydrobromic acid and dimethyl sulfoxide at 90-110 deg, 10-alkyl-2(10H)-phenazinone was obtained as a major product. Brominated dihydrophenazine was isolated in the case of 1,6-dichloro-5,10-dimethyl-5,10-dihydrophenazine.