Ultrasound Assisted Synthesis of Some Novel Bis-Pyridazine Derivatives

摘要

Bis-enaminone 3 was coupled with aryldiazonium chlorides 4a, 4b to afford the bis-arylhydrazonopropanals 6a, 6b. Compounds 6a, 6b could be utilized for the synthesis of a variety of bis-(dimethyl 2,3-dihydropyridazine-3,4-dicarboxylate), bis-(pyridazin-3(2H)-one), bis-(2,3-dihydropyridazine-4-carbonitrile) and bis-(3-imino-2,3-dihydropyridazine) derivatives, under ultrasonic irradiation. A comparative study of aforementioned reactions was carried out under conventional method as well as under ultrasonic irradiation conditions.