SOME SYNTHETIC APPROACHES TO ROPINIROLE (SK-AND-F 101468-A) - A POTENT DOPAMINE RECEPTOR AGONIST

摘要

Three new routes to ropinirole (SK&F 101468-A, 1) are described each involving the preparation of 3-chlorooxindole intermediates of type 3 from beta-nitrostyrenes as the pivotal step. The superiority of sulphonate esters 17a-c as direct precursors to 1 over the bromide 11 is also described. [References: 17]