1,2,4-TRIAZOLES - IMPROVED SYNTHESIS OF 5-SUBSTITUTED 4-AMINO-3-MERCATO-(4H)-1,2,4-TRIAZOLES AND A FACILE ROUTE TO 3,6-DISUBSTITUTED 1,2,4-TRIAZOLO[3,4-B][1,3,4]THIADIAZOLES

摘要

The reaction of thiocarbohydrazide with carboxylic acids at the melting temperature allows an improved preparation of the 5-substituted 4-amino-3-mercapto-1,2,4-triazole heterocycles. The crude 4-amino-5-mercapto-1,2,4-triazoles react easily with carboxylic acids or carboxylic acid chlorides to afford the 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole ring system. [References: 12]