SYNTHESIS AND SPECTRAL PROPERTIES OF 2-METHYLTHIO-3H-4-(PARA-SUBSTITUTED-PHENYL)-7-[(O-,-AND-P-SUBSTITUTED)PHEN YLTHIO]-1,5-BENZODIAZEPINES

摘要

A series of twelve new 2-methylthio-3H-4-(p-substituted phenyl)-7-[(o-, and p-substituted)phenylthio]-1,5-benzodiazepines, which have potentially useful pharmacological properties, has been synthesized by condensing the 3,3-dimercapto-1-(para-substituted-phenyl)-2-propen-1-one with 3,4-diamino phenyl-R-phenylthio ethers, and subsequently the 1H-1,5-benzodiazepine-2-thiones obtained were treated with sodium hydride and methyl iodide. The structure of all products was corroborated by ir, H-1-nmr, C-13-nmr and ms. [References: 8]