DEVELOPMENT OF A HUMAN WHOLE-BODY PHYSIOLOGICALLY-BASED PHARMACOKINETIC (WB-PBPK) MODEL OF LOVASTATIN LACTONE AND CARBOXYLATE (ACID) TO PREDICT HEPATIC CONCENTRATIONS.

Tsakalozou E.; Sampson M.; Wang M. Z.; Brouwer K. L.

首页> 外文期刊>Clinical Pharmacology and Therapeutics >DEVELOPMENT OF A HUMAN WHOLE-BODY PHYSIOLOGICALLY-BASED PHARMACOKINETIC (WB-PBPK) MODEL OF LOVASTATIN LACTONE AND CARBOXYLATE (ACID) TO PREDICT HEPATIC CONCENTRATIONS.

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DEVELOPMENT OF A HUMAN WHOLE-BODY PHYSIOLOGICALLY-BASED PHARMACOKINETIC (WB-PBPK) MODEL OF LOVASTATIN LACTONE AND CARBOXYLATE (ACID) TO PREDICT HEPATIC CONCENTRATIONS.

机译：洛伐他汀内酯和羧酸盐（酸）的人体生理基础药代动力学（WB-PBPK）模型的开发，可预测肝脏浓度。

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《Clinical Pharmacology and Therapeutics》 |2015年第s1期|共1页
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Tsakalozou E.; Sampson M.; Wang M. Z.; Brouwer K. L.;
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中图分类药理学;
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1. DEVELOPMENT OF A HUMAN WHOLE-BODY PHYSIOLOGICALLY-BASED PHARMACOKINETIC (WB-PBPK) MODEL OF LOVASTATIN LACTONE AND CARBOXYLATE (ACID) TO PREDICT HEPATIC CONCENTRATIONS. [J] . Tsakalozou E., Sampson M., Wang M. Z., Clinical Pharmacology and Therapeutics . 2015,第S1期

机译：洛伐他汀内酯和羧酸盐（酸）的人体生理基础药代动力学（WB-PBPK）模型的开发，可预测肝脏浓度。
2. Dynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body physiologically-based pharmacokinetic (WB-PBPK) models [J] . Michaela Vossen, Michael Sevestre, Christoph Niederalt, Theoretical Biology and Medical Modelling . 2007,第1期

机译：使用个体偶联全身基于生理的药代动力学（WB-PBPK）模型动态模拟咪达唑仑和CYP3A4抑制剂伊曲康唑的相互作用
3. A whole-body physiologically based pharmacokinetic (WB-PBPK) model of ciprofloxacin: a step towards predicting bacterial killing at sites of infection [J] . Sadiq Muhammad W., Nielsen Elisabet I., Khachman Dalia, Journal of pharmacokinetics and pharmacodynamics . 2017,第2期

机译：环丙沙星的全身生理学药代动力学（WB-PBPK）模型：朝向感染部位预测细菌杀伤的步骤
4. A Physiologically-Based Pharmacokinetic Model of Methotrexate Incorporating Hepatic Excretion via Multidrug-Resistance-Associated Protein 2 (Mrp2) in Mice, Rats, Dogs, and Humans [C] . Manupat Lohitnavy, Yasong Lu, Ornrat Lohitnavy, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2017

机译：通过小鼠，大鼠，狗和人类，通过多药抗性相关蛋白2（MRP2）掺入肝细胞排泄的生理学上的药代动力学模型
5. Physiologically-based Pharmacokinetic and Pharmacodynamic (PBPK/PD) Predictive Brain Toxicity Computational Model for Organophosphates. [D] . Akwitti, Chukwuma. 2017

机译：基于生理学的药代动力学和药效学（PBPK / PD）预测性有机磷的脑毒性计算模型。
6. Dynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body physiologically-based pharmacokinetic (WB-PBPK) models [O] . Michaela Vossen, Michael Sevestre, Christoph Niederalt, 2007

机译：使用个体偶联全身基于生理的药代动力学（WB-PBPK）模型动态模拟咪达唑仑和CYP3A4抑制剂伊曲康唑的相互作用
7. Dynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body physiologically-based pharmacokinetic (WB-PBPK) models [O] . 2007

机译：使用个体偶联全身基于生理的药代动力学（WB-PBPK）模型动态模拟咪达唑仑和CYP3A4抑制剂伊曲康唑的相互作用

DEVELOPMENT OF A HUMAN WHOLE-BODY PHYSIOLOGICALLY-BASED PHARMACOKINETIC (WB-PBPK) MODEL OF LOVASTATIN LACTONE AND CARBOXYLATE (ACID) TO PREDICT HEPATIC CONCENTRATIONS.

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