Reduced I-123 Ioflupane Binding in Bilateral Diabetic Chorea: Findings With F-18 FDG PET, Tc-99m ECD SPECT, and I-123 MIBG Scintigraphy

摘要

We report a 64-year-old man with diabetic chorea whom we investigated with dopamine transporter SPECT, F-18 FDG PET, Tc-99m ethylcysteinate dimer (ECD) SPECT, and I-123 metaiodobenzylguanidine (MIBG) scintigraphy. Dopamine transporter SPECT revealed reduced I-123 ioflupane binding in the bilateral striatum. F-18 FDG PET showed metabolic dysfunction in the bilateral striatum, as shown in earlier studies. Tc-99m ECD SPECT revealed reduced brain perfusion in the bilateral caudate nucleus and putamen. I-123 MIBG scintigraphy revealed no cardiac sympathetic nerve dysfunction. Our case suggests a possible nigrostriatal presynaptic dopaminergic involvement in diabetic chorea.