Wrong questions, wrong answers? are we getting the drugs we need?

摘要

While medicines usually promote health, they can also be expensive and cause harm. It is therefore important that needed medicines be developed that are safe, effective, and affordable. Unfortunately, progress toward this goal is inconsistent. We argue that forces other than commercialization must be considered and that there is a need to advocate for a drug development process that fills important gaps, reduces clinical uncertainty, and promotes the rational use of medicines.