Is longer duration of proton pump inhibitor trial better for gastroesophageal reflux disease-related non-cardiac chest pain?

摘要

Non-cardiac chest pain (NCCP) is defined as recurrent angina-like or substernal chest pain unrelated to the heart after cardiac evaluation. It is a heterogeneous disorder and the pathophysiology is still poorly understood. Gastroesophageal reflux disease (GERD) has been considered one of the major causes of NCCP. In Western countries, abnormal ambulatory 24-h esophageal pH is present in approximately 50% of NCCP patients. In Asia, approximately 29-40% of NCCP cases are attributable to GERD. However, both typical acid reflux symptoms and endoscopic esophagitis (8-15%) are uncommon in Asian patients with NCCP.