Changes in serum alpha fetoprotein in patients with recurrent hepatocellular carcinoma following hepatectomy

摘要

Background and Aim: To study the change in serum alpha fetoprotein (AFP) of patients with recurrent hepatocellular carcinoma (HCC) after curative resection and to analyze its effect on the survival.Methods: We prospectively collected 981 consecutive patients with post-resectional recurrent HCC between 2005 and 2010 at the Eastern Hepatobiliary Surgery Hospital. According to the change of AFP from the initial stage to recurrent stage, the patients were divided into stable-L (20ng/mL to 20ng/mL, ft = 296), stable-M (20-400 ng/mL to 20-400 ng/mL, ft =102), stable-H (400ng/mL to 400ng/mL, w = 212), decreasing (ft = 287), and increasing (n = 84) groups. The overall survival (OS) and recurrence to death survival (RTDS) were analyzed using Kaplan-Meier method. Multivariate analysis was performed by Cox proportional hazards regression.