Simeprevir plus peginterferon/ribavirin for HCV genotype 1-infected treatment-naive patients in China and South Korea

Wei Lai; Han Tao; Yang Dongliang; Heo Jeong; Shang Jia; Cheng Jun; Chen Xinyue; Xie Qing; Kim Ju-Hyun; Kalmeijer Ronald; Ouwerkerk-Mahadevan Sivi; Hoeben Eva; Lenz Oliver; Verbinnen Thierry; Sinha Rekha; Li MengChun; Scott Jane; Peeters Monika; Witek James

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Simeprevir plus peginterferon/ribavirin for HCV genotype 1-infected treatment-naive patients in China and South Korea

机译：Simeprevir加上聚乙二醇干扰素/利巴韦林治疗HCV基因型1感染的中国和韩国初治患者

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Background and AimApproximately one-third of patients with hepatitis C virus (HCV) genotype (GT) 1 infection live in East Asia. This study evaluated the efficacy, pharmacokinetics, safety, and tolerability of simeprevir plus peginterferon alpha-2a and ribavirin (PR) in HCV GT1-infected, treatment-naive, Asian patients with compensated liver disease.

机译：背景和目标约有三分之一的丙型肝炎病毒（HCV）基因型（GT）1感染患者居住在东亚。这项研究评估了Simeprevir加上聚乙二醇干扰素α-2a和利巴韦林（PR）在HCV GT1感染，未经治疗的亚洲代偿性肝病患者中的疗效，药代动力学，安全性和耐受性。

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来源
《Journal of gastroenterology and hepatology》 |2016年第5期|共9页
作者
Wei Lai; Han Tao; Yang Dongliang; Heo Jeong; Shang Jia; Cheng Jun; Chen Xinyue; Xie Qing; Kim Ju-Hyun; Kalmeijer Ronald; Ouwerkerk-Mahadevan Sivi; Hoeben Eva; Lenz Oliver; Verbinnen Thierry; Sinha Rekha; Li MengChun; Scott Jane; Peeters Monika; Witek James;
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正文语种 eng
中图分类消化系及腹部疾病;
关键词
East Asia; HCV non-structural (NS)3; 4A protease inhibitor; hepatitis C virus; simeprevir; sustained virologic response;

机译：东亚;HCV非结构性（NS）3;4A蛋白酶抑制剂;丙型肝炎病毒;西美普韦;持续的病毒学应答;

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专利

1. Simeprevir plus peginterferon/ribavirin for HCV genotype 1-infected treatment-naive patients in China and South Korea [J] . Wei Lai, Han Tao, Yang Dongliang, Journal of gastroenterology and hepatology . 2016,第5期

机译：Simeprevir加上聚乙二醇干扰素/利巴韦林治疗HCV基因型1感染的中国和韩国初治患者
2. Once-daily simeprevir with peginterferon and ribavirin for treatment-experienced HCV genotype 1-infected patients in Japan: The CONCERTO-2 and CONCERTO-3 studies [J] . IzumiN., HayashiN., KumadaH., Journal of gastroenterology . 2014,第5期

机译：每天一次接受Simeprevir联合聚乙二醇干扰素和利巴韦林治疗在日本有治疗经验的HCV基因型1感染的患者：CONCERTO-2和CONCERTO-3研究
3. Efficacy and safety of a 12-week simeprevir plus peginterferon/ribavirin regimen in treatment-naive HCV genotype 4-infected patients with mild-to-moderate fibrosis [J] . Asselah T., Moreno C., Sarrazin C., Journal of viral hepatitis. . 2015,第Suppla3期

机译：12周的Simeprevir联合聚乙二醇干扰素/利巴韦林方案治疗初治HCV基因型4轻度至中度纤维化患者的疗效和安全性
4. Hepatitis C Virus Genotyping and Serum Anti-F Antibody Detection of HCV Patients in the South of Jiangsu Province of China [C] . Xiao-Zhao Deng, Yun Zhang, Zhen-Yu Diao, International Forum on Progress on Post-Genome Technologies(5'IFPT); 20070910-11; Suzhou(CN) . 2007

机译：苏南地区丙型肝炎患者丙型肝炎病毒基因分型和血清抗F抗体检测
5. Population pharmacokinetics and efficacy of ribavirin in patients with chronic hepatitis C genotype 1 infection. [D] . Jin, Runyan. 2010

机译：利巴韦林在慢性丙型肝炎基因型1感染患者中的群体药代动力学和功效。
6. Pre-existence and Persistence of Resistant Minority Hepatitis C Virus Variants in Genotype 1-Infected Patients Treated With Simeprevir/Peginterferon/Ribavirin [O] . Bart Fevery, Kim Thys, Veerle Van Eygen, 2016

机译：接受Simeprevir / Peginterferon / Ribavirin治疗的基因型1感染患者中的耐药性少数丙型肝炎病毒变异株的存在和持续存在
7. Virology analyses of HCV isolates from genotype 1-infected patients treated with simeprevir plus peginterferon/ribavirin in Phase IIb/III studies [O] . Lenz Oliver, Verbinnen Thierry, Fevery Bart, 2015

机译：在IIb / III期研究中用simeprevir +聚乙二醇干扰素/利巴韦林治疗的基因型1感染患者的HCV分离株的病毒学分析

Simeprevir plus peginterferon/ribavirin for HCV genotype 1-infected treatment-naive patients in China and South Korea

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