Neurocutaneous melanosis: assessment on F-18 FDG and (11C)-methionine PET/CT and MRI.

摘要

Neurocutaneous melanosis is an extremely rare, nonfamilial neurocutaneous syndrome characterized by large cutaneous melanocytic nevi and excessive proliferation of melanocytic cells in the leptomeninges. We present the F-18 FDG and [11C]-methionine PET/CT findings in a 16-year-old boy with neurocutaneous melanosis. Diffuse uptake was noted in the leptomeninges extending into the brain parenchyma with both tracers, which corresponded to hyperintensities on MRI. Histopathology revealed extensive melanocytic infiltration with no evidence of malignancy. The increased radiotracer accumulation may thus reflect overall increased cell glucose and amino acid metabolism of this rare disorder.