Synthes Award For Resident Research On Craniofacial And Brain Injury: effect of cyclosporin A, topiramate, or 100% oxygen as proposed 'neuroprotective' therapies on the neurochemical analytes in patients with severe traumatic brain injury.

摘要

Three separate phase II, mechanistic, clinical have trials recently evaluated the biological and "neuroprotective" effects of Cyclosporin A, topiramate, and 100% oxygen in patients with severe traumatic brain injury (TBI). The current study is a combined analysis of these three trials, and a direct comparison of the effect of these three drugs on the local brain neurochemistry, as assessed by microdialysis.