Paradoxical interictal cerebral cortical hypermetabolism on brain FDG PET in Sturge-Weber syndrome.

摘要

Sturge-Weber syndrome (SWS) is a congenital, noninherited neurocutaneous syndrome, characterized by angiomas located in the facial skin and leptomeninges and often associated with severe epilepsy. We report a paradoxical finding on FDG PET with interictally increased metabolism in the affected hemisphere and contralateral cerebellum in an infant with epilepsy due to SWS. PET imaging was performed to assess the extent and degree of cerebral metabolic impairment before epilepsy surgery. Although the exact mechanism underlying this paradoxical hypermetab-olism remains unclear, it may play an important role in the pathophysi-ologic progression of SWS.