Preparation of a Naltrexone HCI Potentiometric Sensor and Its Application to Pharmaceutical Analysis and Drug Determination in Biological Fluids

摘要

A novel ion selective electrode is fabricated for naltrexone HCI and used in pharmaceutical analysis and drug determination in biological fluids without complicated pretreatments and extractions, using direct potentiometry. The naltrexone complex with sodium tetraphenyl borate (NaTPB) is obtained by in situ soaking PVC membrane electrode in an 1 x 10~3 M naltrexone solution. The sensor exhibited fast, reproducible and linear sub-Nernstian response over concentration range of 1 x 10~5 - 1 x 10~3 M with a detection limit of 5 x 10~6 M. The membrane sensor was successfully applied to the determination of naltrexone in capsules as well as for its determination in urine and plasma samples.