Myeloproliferative Neoplasms: The Role ofMolecular Markers

摘要

The myeloproliferative neoplasms (MPN), formerly known as the myeloproliferative disorders (MPD), are a group of clonal disorders involving hyperproliferation of one or more of the myeloid cell lines (erythrocytic, granulocytic, megakaryocytic). The most common disorders traditionally classified as MPNs are chronic myelogenous leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET), and primary myelo-fibrosis (PMF). Other, less common disorders in this group include chronic neutrophilic leukemia (CNL), chronic eosinophilic leukemia (CEL), mastocytosis, and myeloproliferative neoplasm, unclassifiable (MPN,!!).1 All of these neoplasms are most common in people with a median age of 65 years at diagnosis but have been diagnosed in all age groups. Common presenting signs are fatigue, splenomegaly, and elevated cell counts. Often, there are bleeding or thrombotic symptoms.