MIC evaluation of Candida reference strains and clinical isolates by E-test.

摘要

In the last few years, the incidence of Candida infections has increased significantly x. Although these infections are still mostly caused by Candida albicans, an epidemiological shift of these pathogens to non Candida albicans Candida (NCAC) species has been observed 2. These species have variable levels of susceptibility to antifungal agents, resulting in an increasing need for rapid and precise methods for susceptibility testing. Currently, the Clinical and Laboratory Standards Institute (CLSI) has approved methods for susceptibility testing that include macro and microdilution of the antimicrobial agent in broth 3. However, these methods are not the most adequate for clinical routine due to the intensive work they demand.