Low frequency of ertapenem-resistant intra-abdominal isolates of Escherichia coli from Latin America: susceptibility, ESBL-occurrence, and molecular characterisation (SMART 2008-2009).

Stephen P Hawser; Samuel K Bouchillon; Daryl J Hoban; Robert E Badal; Meredith A Hackel; Christine A Lascols; Maria V Villegas; Flavia Rossi

摘要

The Study for Monitoring Antimicrobial Resistance Trends is an ongoing multi-year surveillance study that tracks worldwide antimicrobial resistance trends among aerobic and facultatively anaerobic Gram-negative bacilli isolated from intra-abdominal infections. During 2008-2009, 1366 isolates of Escherichia coli were collected from 19 investigator sites in 11 Latin American countries. Of the 1366 isolates, 323 (23·6%) were extended spectrum beta-lactamase (ESBL)-positive. Overall, the most effective agents tested were imipenem, ertapenem, and amikacin with susceptibilities of ?96%. Against ESBL-positive isolates, only imipenem and ertapenem exhibited susceptibility ?90%. Based on the use of the new Clinical and Laboratory Standards Institute clinical breakpoints for ertapenem (resistance ?1 μg/ml), resistance to ertapenem among all E. coli isolates was only 0·3% (4/1366) throughout the region, ranging from 0% in several countries up to 1·2% in Ecuador. Against ESBL-positive isolates only, resistance to ertapenem in Latin America overall was 0·9% (3/323), with a maximum of 9·1% (1/11) observed in Argentina. </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><title />监测抗菌素耐药性趋势的研究是一项正在进行的多年监测研究，追踪了从腹腔内感染中分离出的需氧和兼性厌氧革兰氏阴性细菌在全球范围内的耐药性趋势。在2008-2009年期间，从11个拉丁美洲国家/地区的19个研究人员地点收集了1366株大肠杆菌。在1366株分离物中，有323株（23·6％）呈超广谱β-内酰胺酶（ESBL）阳性。总体而言，测试的最有效药物是亚胺培南，厄他培南和丁胺卡那霉素，敏感性为96％。对于ESBL阳性分离株，仅亚胺培南和厄他培南表现出敏感性≥90％。根据新的临床和实验室标准协会对厄他培南的临床断点的使用（耐药性≥1μg/ ml），整个区域内所有大肠杆菌中对厄他培南的耐药性仅为0·3％（4/1366）从几个国家的0％到厄瓜多尔的1·2％。仅针对ESBL阳性分离株，拉丁美洲总体上对厄他培南的耐药率为0·9％（3/323），在阿根廷最大为9·1％（1/11）。 </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-34452/'>《Journal of chemotherapy》</a> <b style="margin: 0 2px;">|</b><span>2012年第1期</span><b style="margin: 0 2px;">|</b><span>共6页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Stephen P Hawser&option=202" target="_blank" rel="nofollow">Stephen P Hawser;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Samuel K Bouchillon&option=202" target="_blank" rel="nofollow">Samuel K Bouchillon;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Daryl J Hoban&option=202" target="_blank" rel="nofollow">Daryl J Hoban;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Robert E Badal&option=202" target="_blank" rel="nofollow">Robert E Badal;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Meredith A Hackel&option=202" target="_blank" rel="nofollow">Meredith A Hackel;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Christine A Lascols&option=202" target="_blank" rel="nofollow">Christine A Lascols;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Maria V Villegas&option=202" target="_blank" rel="nofollow">Maria V Villegas;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Flavia Rossi&option=202" target="_blank" rel="nofollow">Flavia Rossi;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1476.html" title="治疗学">治疗学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> </p> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704014299993.html">Low frequency of ertapenem-resistant intra-abdominal isolates of Escherichia coli from Latin America: susceptibility, ESBL-occurrence, and molecular characterisation (SMART 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tuijian_authcolor">,孙桂芝</a> <span> <a href="/journal-cn-5956/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 临床肺科杂志 </a> </span> <span> . 2007</span><span>,第006期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020314224435.html">上海市部分医院致泻性大肠杆菌和弯曲菌临床分离株的耐药性与分子分型</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=潘海建&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 潘海建</a> <span> . 2016</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06130412056835.html">ESCHERICHIA COLI STRAIN WITH MUTATIONS FOR THE HIGH PRODUCTION OF RECOMBINANT NUCLEIC ACIDS WITH A LOW ACCUMULATION OF ACETATE AND THE USE THEREOF IN CULTURES OF HIGH MOLECULAR DENSITY IN BATCH MODE.</a> <b>[P]</b> . <span> 外国专利：  MX342245B </span> <span> . 2016-09-14</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：带有突变的大肠埃希氏菌以高产量生产重组核酸且乙酸盐含量低，并且在批量模式下在高分子密度培养中的应用。 </span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06130420289536.html">ESCHERICHIA COLI STRAIN WITH MUTATIONS FOR THE HIGH PRODUCTION OF RECOMBINANT NUCLEIC ACIDS WITH A LOW ACCUMULATION OF ACETATE AND THE USE THEREOF IN CULTURES OF HIGH MOLECULAR DENSITY IN BATCH MODE.</a> <b>[P]</b> . <span> 外国专利：  MX2011013392A </span> <span> . 2013-06-17</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：带有突变的大肠埃希氏菌菌株，用于以低积累乙酸盐的方式高产量生产重组核酸，并用于批量生产高分子密度的文化。 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> 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