Fluoroalkylation of pent-4-en-1-ols initiated by sodium dithionite to synthesize fluorine-containing tetrahydrofuran derivatives

摘要

Fluoroalkylation of pent-4-en-1-ols with RCF2I initiated by Na2S2O4 was carried out at 5-10 deg C in aqueous acetonitrile affording corresponding adducts,which were converted to fluoroalkyl tetrahydrofurans by heating in DMF or acetonitrile,providing a convenient method for the synthesis of fluorine-containing tetrahydrofuran derivatives.