Simple procedure for preparation of alpha-fluoro esters by fluorination of ester enol silyl ethers with perchloryl fluoride

摘要

Fluorination of ester enol silyl ethers in THF at room temperature using diluted perchloryl fluoride (FClO_3) in the presence of ca. 0.5 M eq. of t-BuNH_2 as an additive produced the corresponding alpha-fluoro esters in over 80% yields.