Reaction of #beta#-fluorinated vinamidinium salts with Grignard reagents and reducing agents New facile and efficient route to fluorinated allylamines

摘要

#beta#-Fluorinated vinamidinium salts (1) readily reacted with a series of Grignard reagents in tetrahydrofura, followed by the action of reducing agents at room temperature, to proudce stereospecifically the corresponding fluorinated allylamines (4 and 5) in good to excellent yields.