Effect of Antagonists of Serotonin Receptors on Modulation with Serotonin of Synaptic Activity of Projectional Neurons of Rat Amygdala Dorsolateral Nucleus

摘要

The work studies role of different receptor types of serotonin (5-hydroxytryptamine; 5-HT) in the process of synaptic activity modulation with 5-HT of rat dorsolateral amygdala projection neurons. The selective antagonist of 5-HT receptors methylsergid maleate was shown to suppress the 5-HT inhibitory action on amplitude of the postsynaptic currents evoked by glutamate and GABA, whereas the antagonist of 5-HT receptors SDZ202-557 produced no effect on the above-mentioned 5-HT action. The obtained action indicates that the 5-HT modulatory effect on the projectional neuron synaptic inputs is mediated by 5-HT receptors of the 1 and 2 types.