Hemodynamic and electroencephalographic effects of epidural buprenorphine during orthopedic hindlimb surgery in sheep:a comparison with intramuscular buprenorphine and epidural saline

摘要

Epidural opioids exert segmentally limited spinal analgesia by acting at dorsal horn neurons. While the spinal cord may be the predominant site of action for hydrophilic opioids such as morphine,initial suprspinal effects have been suggested for lipophilic opioids such as buprenorphine. In view of significant systemic effects,the value of epidural administration of lipophilic opioids in human patients has been questioned.