Synthesis and evaluation of delta-lactams (piperazones) as elastase inhibitors.

Seibel J; Brown D; Amour A; Macdonald SJ; Oldham NJ; Schofield CJ

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Synthesis and evaluation of delta-lactams (piperazones) as elastase inhibitors.

机译：合成和评估δ-内酰胺（哌嗪酮）作为弹性蛋白酶抑制剂。

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摘要

A series of monocyclic delta-lactams (piperazones) was prepared and analysed as inhibitors of porcine pancreatic elastase and human neutrophil elastase.

机译：制备了一系列单环δ-内酰胺（哌嗪酮），并作为猪胰弹性蛋白酶和人嗜中性粒细胞弹性蛋白酶的抑制剂进行了分析。

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《Bioorganic and Medicinal Chemistry Letters》 |2003年第3期|共3页
作者
Seibel J; Brown D; Amour A; Macdonald SJ; Oldham NJ; Schofield CJ;
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正文语种 eng
中图分类基础医学;
关键词
Lactams; Pancreatic Elastase antagonists and inhibitors; Serine Proteinase Inhibitors; 内酰胺类; 丝氨酸蛋白酶抑制剂;

机译：Lactams;Pancreatic Elastase antagonists and inhibitors;Serine Proteinase Inhibitors;内酰胺类;丝氨酸蛋白酶抑制剂;

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1. Synthesis and evaluation of delta-lactams (piperazones) as elastase inhibitors. [J] . Seibel J, Brown D, Amour A, Bioorganic and Medicinal Chemistry Letters . 2003,第3期

机译：合成和评估δ-内酰胺（哌嗪酮）作为弹性蛋白酶抑制剂。
2. Synthesis and evaluation of delta-lactams (piperazones) as elastase inhibitors. [J] . Seibel J, Brown D, Amour A, Bioorganic and Medicinal Chemistry Letters . 2003,第3期

机译：合成和评估δ-内酰胺（哌嗪酮）作为弹性蛋白酶抑制剂。
3. Design and synthesis of hydrazinopeptides and their evaluation as human leukocyte elastase inhibitors. [J] . Guy L, Vidal J, Collet A, Journal of Medicinal Chemistry . 1998,第24期

机译：肼基肽的设计与合成及其作为人白细胞弹性蛋白酶抑制剂的评估。
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机译：中性粒细胞弹性蛋白酶抑制剂Lys44349- 2H4的合成及其代谢物，LY575481- 2H4
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机译：新的二取代的咪唑（吡啶嗪衍生物为选择性HAPIN抑制剂的设计。合成结合模式和抗癌生物学评估
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8. Synthesis of Elastase Inhibitors. [R] . powers,james c. 1976

机译：弹性蛋白酶抑制剂的合成。

Synthesis and evaluation of delta-lactams (piperazones) as elastase inhibitors.

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