Association of Tumor Necrosis Factor (TNF) promoter polymorphisms with plasma TNF-alpha levels and susceptibility to diabetic nephropathy in North Indian population

摘要

Aim: The concept of diabetic nephropathy (DN) as a metabolic disease is now being replaced by chronic low-grade inflammatory disease. Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine which plays an important role in the pathogenesis and clinical outcome of DN. Therefore, this work was planned to evaluate the association of -863C/A (rs1800630) and -1031T/C (rs1799964) polymorphisms in TNF gene with plasma TNF-alpha levels and DN among subjects with type 2 diabetes (T2DM) in a population from North India.