White Mineral Trioxide Aggregate Induces Migration and Proliferation of Stem Cells from the Apical Papilla

摘要

Interest in regenerative endodontics has increased substantially in recent years, encouraged by successful clinical case reports of treated immature necrotic teeth (1-3). A number of these cases have shown that after disinfection with triple antibiotic paste or calcium hydroxide, the use of mineral trioxide aggregate (MTA) as capping material over an induced blood clot will continue root development (2-4). Lovelace et al (1) have shown that the induction of bleeding at the apex results in a higher concentration of mesenchymal stem cells (MSCs) than is found in the systemic circulation. Although the exact source of these stem cells is as yet unknown, the apical papilla is the likely origin (1). The understanding of the effects of MTA on the stem cells from the apical papilla is critically important to optimizing clinical regenerative endodontics protocols.