Purity Analysis Method of Dihydroxylammonium 5,5 '-Bistetrazole-1,1 '-diolate (TKX-50)

摘要

A method for purity analysis of dihydroxylammonium 5,5'-bistetrazole-1,1'-diolate (TKX-50) using high-performance liquid chromatography (HPLC) was established by optimizing the chromatographic conditions: the detection wavelength was set at 200nm, and the sample was separated by reverse-phase column (SinoChrom ODS-BP, 4.6mmx200mm, 5m) using binary mobile phase acetonitrile and water (volume ratio of 50/50) with a flow rate of 1.0mL/min at column temperature of 25 degrees C. Normalization method, external standard method, and internal standard method were used to analyze the purity of TKX-50. The results indicate that the precision and accuracy of each method can satisfy the requirements of product analysis; however, the external standard method possesses higher accuracy and precision by comparison and is suggested to analyze the purity of TKX-50.