Changes in aortic pulse wave velocity of patients undergoing endovascular repair of abdominal aortic aneurysms

摘要

Purpose: To assess changes in pulse wave velocity (PWV), a valid index of arterial stiffness, in patients undergoing endovascular repair (EVAR) of abdominal aortic aneurysm (AAA). Arterial stiffness is an independent marker of all-cause mortality and cardiovascular morbidity and mortality. Methods: Forty-eight consecutive male patients (mean age 71±4 years) underwent elective EVAR (AAA group) after exclusion of patients with Marfan syndrome or other collagenrelated disorders. Thirty-one age-matched men (mean age 69±5 years) without overt cardiovascular disease served as controls. PWV and clinical parameters were determined at baseline in both groups and after 6 months in the AAA group. Results: At baseline, the groups did not differ in demographic characteristics, lipid profile, or blood pressure levels (p0.05). PWV was considerably higher in AAA than controls (p0.001). PWV positively correlated with mean blood pressure, AAA diameter, and age in univariate and multivariate analysis (R 2=0.498, p=0.008). At 6 months after EVAR, PWV significantly increased from 13.11±3.57 m/s to 16.41±2.33 m/s (p,0.001) in the AAA group. Conclusion: Patients with AAA present with significantly elevated PWV levels compared to controls, and stent-graft repair is associated with a significant increase in the PWV. Whether those changes contribute to the cardiovascular risk in AAA patients needs further investigation.