Clinical implications of a recent adjustment to the high-sensitivity cardiac troponin T assay: User beware

摘要

The occurrence of this problem is not surprising, considering the challenges presented by the quality assurance of hs assays. We have been perplexed by the fact that early data suggested that most healthy individuals have detectable values. In the PEACE (Prevention of Events with Angiotensin Converting Enzyme Inhibition) study (1), 97.7% of participants had a value above the limit of detection, which was 1 pg/mL (1 ng/L) at the time with a precommer-cial assay. In the original validation by Giannitsis et al. (2 ), 80% of puta-tively healthy participants had values above the limit of the blank.