Profile of serum pregnancy-associated plasma protein a after sustained subcutaneous low molecular weight heparin administration in patients with cerebrovascular diseases.

摘要

Pregnancy-associated plasma protein A (PAPP-A), considered a surrogate marker of increased risk of unstable atherosclerosis and its complications (1, 2), is revers-ibly bound to the surfaces of several cell types because of heparin's effective competition for surface binding (3). Heparins, however, especially low molecular weight heparins (LMWH), are routinely used for the treatment and prevention of thromboembolism. Because of the observation that intravenous administration of LMWH and heparin elicits a rapid increase in serum PAPP-A (4), we investigated the time profile of the effect of subcutaneous LMWH administration on PAPP-A concentration in a cerebrovascular disorder population.