Hypolipidaemic potential of seaweeds in normal, triton-induced and high-fat diet-induced hyperlipidaemic rats

摘要

Numerous epidemiological studies have shown that long-term hyperlipidaemia is associated with coronary heart disease. The dietary and pharmacological lowering of elevated plasma LDL cholesterol appears to be one of the methods to reduce the development of atherosclerosis and related heart diseases. During this study, ethanol extracts of 13 seaweed species were tested for hypolipidaemic potential in normal rats, some of these caused positive effect by lowering the total cholesterol, triglyceride and LDL cholesterol with increase in HDL cholesterol. Efficacy of eight seaweeds Dictyota dichotoma var. intrica, Jolyna laminarioides, Melanothamnus afaqhusainii, Sargassum binderi, Sargassum swartzii, Halimeda tuna, Spatoglossum variabile, and Solieria robusta was also examined in triton-induced hyperlipidaemic rats. Three potential seaweeds J. laminarioides, S. binderi and M. afaqhusainii were further evaluated in high-fat diet-induced hyperlipidaemic rats. These seaweeds showed effective hypolipidaemic potential in triton-induced and high-fat diet-induced hyperlipidaemic rat models. Liver and cardiac enzymes like LDH, ALP, ASAT and ALAT were not adversely affected by seaweeds. Hypolipidaemic potential of some of the seaweeds is comparable with common hypolipidaemic drugs such as bezafibrate (Lipocor) and fenofibrate (Fenoget).