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Phenotypic diversity of Campylobacter isolates from sporadic cases of human enteritis in the UK

机译:英国散发性人类肠炎病例中弯曲杆菌分离株的表型多样性

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Aims: The aim of this study was to identify and subtype a large collection of isolates of Campylobacter spp. to quantify diversity among strains causing human disease from geographically diverse sources in the United Kingdom. Methods and Results: Isolates were characterized by the Penner serotyping scheme, Preston phage typing and biotyping methods. The diversity index calculated from the combined results of all three methods was 0.997 and indicated that isolates form sporadic cases of infection are very diverse. Strong associations between common phagetypes (PG52, PG121 and PG55) and the three most common serotypes (HS1, HS2 and HS4) found in the study were evident. Conclusions: Strains of C. jejuni causing human infections in the Untied Kingdom are very phenotypically diverse. Individual strains characterized by serotype, phagetype and biotype were detected throughout the 7-month study period and from geographically distinct sources, indicating an unrecognized outbreak or other epidemiologically significant source of human infection. Significance and Impact of the Study: The low frequency incidence of most C. jejuni strains should enable easy recognition of outbreaks by strain type surveillance at local, regional and national level in the United Kingdom. The characterization of common strain profiles in this study by simple phenotypic methods could provide the basis for strain specific epidemiological studies for reservoirs of infection and transmission routes for human infection.
机译:目的:本研究的目的是鉴定弯曲杆菌属菌种的大量分离株并将其亚型化。从英国不同地理来源量化导致人类疾病的菌株之间的多样性。方法和结果:分离株通过Penner血清分型,Preston噬菌体分型和生物分型方法进行表征。从这三种方法的综合结果计算得出的多样性指数为0.997,表明散发感染病例的分离株非常多样化。在研究中发现的常见噬菌体类型(PG52,PG121和PG55)与三种最常见的血清型(HS1,HS2和HS4)之间存在很强的联系。结论:在解开王国中引起人感染的空肠弯曲杆菌菌株在表型上非常多样。在整个7个月的研究期间,从地理上不同的来源中检测到了以血清型,噬菌体型和生物型为特征的单个菌株,这表明未识别的暴发或其他流行病学上重要的人类感染源。该研究的意义和影响:在英国,大多数空肠弯曲杆菌菌株的低频发生率应该可以通过菌株类型监测轻松识别出暴发。在本研究中,通过简单的表型方法表征常见的菌株谱,可为针对感染库和人类感染传播途径的菌株特异性流行病学研究提供基础。

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