Inosine triphosphate pyrophosphohydrolase activity: more accurate predictor for ribavirin-induced anemia in hepatitis C infected patients than ITPA genotype

Peltenburg Nicole Chantal; Bakker Jaap A.; Vroemen Wim H. M.; de Knegt Robert J.; Leers Mathie P. G.; Bierau Jorgen; Verbon Annelies

首页> 外文期刊>Clinical chemistry and laboratory medicine: CCLM >Inosine triphosphate pyrophosphohydrolase activity: more accurate predictor for ribavirin-induced anemia in hepatitis C infected patients than ITPA genotype

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Inosine triphosphate pyrophosphohydrolase activity: more accurate predictor for ribavirin-induced anemia in hepatitis C infected patients than ITPA genotype

机译：肌苷三磷酸焦磷酸水解酶活性：丙型肝炎感染患者中病毒唑引起的贫血的预测指标比ITPA基因型更准确

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Background: ITPA polymorphisms have been associated with protection against ribavirin-induced anemia in chronic hepatitis C (HCV) patients. Here we determined the association of inosine triphosphate pyrophosphohydrolase (inosine triphosphatase or ITPase) enzyme -activity with ITPA genotype in predicting ribavirin-induced anemia.

机译：背景：ITPA多态性与慢性丙型肝炎（HCV）患者抗病毒唑引起的贫血的保护作用有关。在这里，我们确定了肌苷三磷酸焦磷酸水解酶（肌苷三磷酸酶或ITPase）酶活性与ITPA基因型在预测利巴韦林引起的贫血中的关联。

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《Clinical chemistry and laboratory medicine: CCLM》 |2015年第12期|共9页
作者
Peltenburg Nicole Chantal; Bakker Jaap A.; Vroemen Wim H. M.; de Knegt Robert J.; Leers Mathie P. G.; Bierau Jorgen; Verbon Annelies;
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正文语种 eng
中图分类诊断学;
关键词
hepatitis C; inosine triphosphatase; inosine triphosphate pyrophosphohydrolase; ITPA; ITPase; ribavirin-induced anemia;

机译：丙型肝炎;肌苷三磷酸酶;肌苷三磷酸焦磷酸水解酶;ITPA;ITPase;利巴韦林引起的贫血;

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1. Inosine triphosphate pyrophosphohydrolase activity: more accurate predictor for ribavirin-induced anemia in hepatitis C infected patients than ITPA genotype [J] . Peltenburg Nicole Chantal, Bakker Jaap A., Vroemen Wim H. M., Clinical chemistry and laboratory medicine: CCLM . 2015,第12期

机译：肌苷三磷酸焦磷酸水解酶活性：丙型肝炎感染患者中病毒唑引起的贫血的预测指标比ITPA基因型更准确
2. ITPA gene variation and ribavirin-induced anemia in patients with genotype 2 chronic hepatitis C treated with sofosbuvir plus ribavirin [J] . Murakawa Miyako, Asahina Yasuhiro, Nagata Hiroko, Hepatology research: the official journal of the Japan Society of Hepatology . 2017,第11期

机译：用Sofosbuvir Plus利巴韦林治疗的基因型2慢性丙型肝炎患者的ITPA基因变异和利巴韦林诱导的血症
3. Efficacy of splenectomy in preventing anemia in patients with recurrent hepatitis C following liver transplantation is not dependent on inosine triphosphate pyrophosphatase genotype [J] . MotomuraT., KogaE., TaketomiA., Hepatology research: the official journal of the Japan Society of Hepatology . 2012,第3期

机译：脾切除术在预防肝移植术后复发性丙型肝炎患者贫血中的作用并不取决于肌苷三磷酸焦磷酸酶基因型
4. HLA-C gene in Hepatitis C Virus infected Patients in Egypt, to estimate the relation between HLA-C gene and Interferon/Ribavirin as treatment for hepatitis C virus [C] . SHADEN MUAWIA HANAFY, AMAL AHMED ABBAS, SAFY KABEEL ALY MANSOUR International Conference on Cellular and Molecular Biology, Biophysics and Bioengineering . 2015

机译：HLA-C基因在丙型肝炎病毒中感染埃及患者，估计HLA-C基因和干扰素/利巴韦林与丙型肝炎病毒治疗的关系
5. Ribavirin systemic and intracellular exposure and its role on viral response and anemia in chronic hepatitis c genotype 1 infection [D] . Wu, Liviawati Sutjandra. 2015

机译：利巴韦林全身和细胞内暴露及其在慢性丙型肝炎基因型1感染中对病毒反应和贫血的作用
6. An Index to Predict Ribavirin-Induced Anemia in Asian Patients With Chronic Genotype 1 Hepatitis C [O] . Sheng-Hung Chen, Cheng-Yuan Peng, Hsueh-Chou Lai, 2015

机译：预测亚洲慢性C型基因型丙型肝炎患者利巴韦林引起的贫血的指标
7. Pre-treatment role of inosine triphosphate pyrophosphatase polymorphism for predicting anemia in Egyptian hepatitis C virus patients [O] . Walaa H Ahmed, Norihiro Furusyo, Saad Zaky, 2013

机译：肌苷三磷酸焦磷酸酶多态性在埃及丙型肝炎病毒患者贫血预测中的作用

Inosine triphosphate pyrophosphohydrolase activity: more accurate predictor for ribavirin-induced anemia in hepatitis C infected patients than ITPA genotype

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