Octreotide-conjugated PAMAM for targeted delivery to somatostatin receptors over-expressed tumor cells

Peng Jianqing; Qi Xiaole; Chen Yi; Ma Ning; Zhang Ziwei; Xing Jiaxu; Zhu Xuehua; Li Zhengrong; Wu Zhenghong

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Octreotide-conjugated PAMAM for targeted delivery to somatostatin receptors over-expressed tumor cells

机译：奥曲肽偶联的PAMAM可定向递送至生长抑素受体过度表达的肿瘤细胞

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摘要

Purpose: An octreotide-conjugated polyamidoamine (PAMAM) dendrimer was synthesized and employed as nanocarriers of methotrexate (MTX), for targeting to the somatostatin receptors over-expressed tumor cells.

机译：目的：合成奥曲肽共轭聚酰胺酰胺（PAMAM）树状大分子并用作甲氨蝶呤（MTX）的纳米载体，以靶向过度表达生长抑素受体的肿瘤细胞。

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来源
《Journal of drug targeting》 |2014年第10期|共11页
作者
Peng Jianqing; Qi Xiaole; Chen Yi; Ma Ning; Zhang Ziwei; Xing Jiaxu; Zhu Xuehua; Li Zhengrong; Wu Zhenghong;
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正文语种 eng
中图分类药学;
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Methotrexate; octreotide; polyamidoamine; receptor-mediated endocytosis; tumor targeting;

机译：甲氨蝶呤;奥曲肽;聚酰胺胺;受体介导的内吞作用;肿瘤靶向;

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专利

1. Octreotide-conjugated PAMAM for targeted delivery to somatostatin receptors over-expressed tumor cells [J] . Peng Jianqing, Qi Xiaole, Chen Yi, Journal of drug targeting . 2014,第1a10期

机译：奥曲肽偶联的PAMAM可定向递送至生长抑素受体过度表达的肿瘤细胞
2. Development of octreotide-conjugated polymeric prodrug of bufalin for targeted delivery to somatostatin receptor 2 overexpressing breast cancer in vitro and in vivo [J] . Tao Liu, Tingting Jia, Xia Yuan, International Journal of Nanomedicine . 2016,第3期

机译：蟾蜍灵奥曲肽共轭聚合物前药的开发，可在体内外靶向递送至生长抑素受体2过表达的乳腺癌
3. Octreotide-Modified Polymeric Micelles as Potential Carriers for Targeted Docetaxel Delivery to Somatostatin Receptor Overexpressing Tumor Cells [J] . Yuan Zhang, Xueqing Wang, Jiancheng Wang, Pharmaceutical Research . 2011,第5期

机译：奥曲肽修饰的聚合物胶束作为靶向多西他赛递送至生长抑素受体过表达肿瘤细胞的潜在载体
4. Novel Camptothecin Somatostatin Conjugate in Treatment of Tumor Cells Expressing sst2 Receptors [C] . Philip G. Kasprzyk, Ann V. Fiore, Yeelana Shen American Peptide Symposium . 2013

机译：新型Camptothecin Somatostatin缀合物治疗表达SST2受体的肿瘤细胞
5. Engineering tumor-targeted poly(amidoamine) (PAMAM) dendrimers for improved penetration and cellular delivery of short-interfering RNA (siRNA) through solid tumors [D] . Waite, Carolyn Leigh 2011

机译：工程化靶向肿瘤的聚（酰胺基胺）（PAMAM）树状大分子，以提高短干扰RNA（siRNA）通过实体瘤的渗透和细胞递送
6. Development of octreotide-conjugated polymeric prodrug of bufalin for targeted delivery to somatostatin receptor 2 overexpressing breast cancer in vitro and in vivo [O] . Tao Liu, Tingting Jia, Xia Yuan, 1988

机译：蟾蜍灵奥曲肽共轭聚合物前药的开发，可在体内外靶向递送至生长抑素受体2过表达的乳腺癌
7. Development of octreotide-conjugated polymeric prodrug of bufalin for targeted delivery to somatostatin receptor 2 overexpressing breast cancer in vitro and in vivo [O] . Tingting Jia, Tao Liu, Yi Yuan, 2016

机译：偶萝卜素缀合聚合物前药的偶然蛋白缀合聚合物前药，用于在体外和体内过表达乳腺癌的生长抑血素受体2

Octreotide-conjugated PAMAM for targeted delivery to somatostatin receptors over-expressed tumor cells

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