Effect of Different Permeation Enhancers on Topical Miconazole Nitrate Preparations

摘要

Miconazole nitrate was formulated into different topical preparations, including gels with different polymers, ointments as oleaginous, water-soluble bases and cream. In vitro skin permeation studies through rabbit skin to a receptor medium of (1:1) Methanol: phosphate buffer (pH 6) For a period of 8 hour was studied. Different chemical enhancers as menthol, isopropyl myristate (IPM), oleic acid and ethanol, were incorporated into miconazole carbopol 934 P gel in different concentrations. They showed improved increase in Flux through rabbit skin. The best formula which showed significant flux was miconazole carbopol 934 p gel containing 10% menthol with the highest permeation of miconazole nitrate.