Chitosan-DNA Particles for DNA Delivery: Effect of Chitosan Molecular Weight on Formation and Release Characteristics

Moran MC; Laranjeira T; Ribeiro A; Miguel MG; Lindman B

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Chitosan-DNA Particles for DNA Delivery: Effect of Chitosan Molecular Weight on Formation and Release Characteristics

机译：用于DNA传递的壳聚糖-DNA颗粒：壳聚糖分子量对形成和释放特性的影响

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Novel DNA-chitosan particles were prepared based on associative phase separation and interfacial diffusion. These particles formed at water/water emulsion type interfaces were characterized with respect to several properties including stability, DNA conformational state, and entrapment and release of DNA. In particular it was found that the chitosan molecular weight is a good controlling parameter.

机译：基于缔合相分离和界面扩散制备了新型的DNA-壳聚糖颗粒。这些颗粒在水/水乳液型界面处形成，具有多种特性，包括稳定性，DNA构象状态以及DNA的捕获和释放。特别地，发现壳聚糖分子量是良好的控制参数。

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《Journal of Dispersion Science and Technology》 |2009年第10期|共6页
作者
Moran MC; Laranjeira T; Ribeiro A; Miguel MG; Lindman B;
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正文语种 eng
中图分类胶体化学（分散体系的物理化学）;
关键词
Chitosan; DNA gel particles; DNA release;

机译：壳聚糖;DNA凝胶颗粒;DNA释放;

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专利

1. Chitosan-DNA Particles for DNA Delivery: Effect of Chitosan Molecular Weight on Formation and Release Characteristics [J] . Moran MC, Laranjeira T, Ribeiro A, Journal of Dispersion Science and Technology . 2009,第10期

机译：用于DNA传递的壳聚糖-DNA颗粒：壳聚糖分子量对形成和释放特性的影响
2. Studies on the condensation of depolymerized chitosans with DNA for preparing chitosan-DNA nanoparticles for gene delivery applications. [J] . Morris VB, Neethu S, Abraham TE, Journal of biomedical materials research. Part B, Applied biomaterials. . 2009,第2期

机译：将解聚的壳聚糖与DNA缩合以制备可用于基因传递的壳聚糖DNA纳米颗粒的研究。
3. Studies on the condensation of depolymerized chitosans with DNA for preparing chitosan-DNA nanoparticles for gene delivery applications. [J] . Morris VB, Neethu S, Abraham TE, Journal of biomedical materials research. Part B, Applied biomaterials. . 2009,第2期

机译：用DNA对脱聚壳聚糖的凝结制备基因递送应用的壳聚糖-DNA纳米粒子的缩合研究。
4. EFFECT OF MOLECULAR WEIGHT AND DEGREE OF DEACETYLATIONON CHITOSAN-DNA NANOPARTICLES [C] . Min Huang, Chee Wai Fong, Eugene Khor, Controlled Release Society 31st annual meeting transactions: abstracts . 2004

机译：分子量和脱乙酰度对壳聚糖-DNA纳米粒子的影响
5. Chitosan-DNA nanoparticles: Synthesis, characterization, subcellular transport and oral delivery of genetic vaccines. [D] . Roy, Krishnendu. 2000

机译：壳聚糖-DNA纳米颗粒：遗传疫苗的合成，表征，亚细胞运输和口服递送。
6. Evaluation of In Vivo Transfection Efficiency of Eudragit Coated Nanoparticles of Chitosan-DNA: A pH-sensitive System Prepared for Oral DNA Delivery [O] . Sedigheh Momenzadeh, Abdorrahim Sadeghi, Nasimeh Vatandoust, 2015

机译：评价Eudragit包被的壳聚糖-DNA纳米粒子的体内转染效率：制备用于口服DNA传递的pH敏感系统。
7. Chitosan-DNA polyelectrolyte complex: Influence of chitosan characteristics and mechanism of complex formation [O] . Lourdes Mónica Bravo-Anaya, Karla Gricelda Fernández-Solís, Julien Rosselgong, 2019

机译：壳聚糖-DNA聚电解质复合物：壳聚糖特性的影响及复杂形成的机理

Chitosan-DNA Particles for DNA Delivery: Effect of Chitosan Molecular Weight on Formation and Release Characteristics

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