High specificity but low sensitivity of the cartilage oligomeric matrix protein (COMP) test in rheumatoid arthritis and osteoarthritis.

摘要

The thrombospondins (TSP) are a family of extracellular proteins involved in tissue genesis and remodeling. The cartilage oligomeric matrix protein (COMP), also known as (TSP-5), is expressed in cartilage, tendon, vitreous, and vascular smooth muscle cells (1). Serum COMP may predict joint damage in rheumatoid arthritis (RA) (2). Increased serum COMP was reported in osteoarthritis (OA), and after cartilage injury (3). In this study, we evaluated serum concentrations of COMP in patients with RA and OA. We also evaluated the diagnostic performance of the COMP test.