Treatment of photoaging with a very superficial Er:YAG laser in combination with a broadband light source.

摘要

BACKGROUND AND OBJECTIVE: Studies documenting improvement following combined laser and light-based devices are needed. The objective of this study was to evaluate clinical, histological, and ultrastructural changes in photodamaged facial skin following sequential treatment with ablative superficial erbium:YAG (Er:YAG) laser peels and nonablative intense pulsed light, or broadband light (BBL), treatments. STUDY DESIGN/MATERIALS AND METHODS: Fifteen subjects with photodamaged facial skin and Fitzpatrick skin types I to III underwent 3 monthly treatments with the Profile system (Sciton, Inc, Palo Alto, CA) utilizing very superficial MicroLaserPeel settings of 2.5 to 5.0 J/cm2 and BBL settings of 515-, 560-, or 590-nm filters, 10-msec pulse duration, and fluences of 12 J/cm2. Five subjects underwent pre- and post-treatment postauricular skin biopsies for evaluation of treatment-induced light and electron microscopic changes. RESULTS: Twelve subjects completed the study. Both blinded evaluator and subject assessment of clinical changes documented significant improvement in photodamaged skin, with the greatest improvement achieved in overall appearance and epidermal dyspigmentation. These results were largely maintained at 3 months following the last treatment. Light microscopy showed changes in the epidermis, collagen, and elastic fibers consistent with a wound repair mechanism to the depth of 250 to 350 microns. Electron microscopy revealed a slight decrease in the average collagen fiber thickness, pointing to an increase in type III collagen. CONCLUSION: A protocol utilizing multiple combined superficial Er:YAG ablative treatments and nonablative BBL treatments lead to a significant improvement in the clinical signs of photodamaged skin, with histological and ultrastructural evidence of new collagen formation.