A prospective randomized evaluation of cyanoacrylate glue devices in the closure of surgical wounds

摘要

Background: The use of medical adhesives for topical wound closure is gaining in popularity over conventional wound closure materials such as sutures and staples. Adhesives provide advantages in both wound closure and patient management with good cosmetic outcome and surgeon and patient satisfaction reported. Objective: To compare the use of two currently marketed medical adhesives; LiquiBand? Flow Control and High Viscosity Dermabond? for the topical closure of surgical incisions. Methods: In a prospective blinded manner, subjects were randomly assigned LiquiBand? or Dermabond? for topical closure of a surgical incision. Variables compared included ease of use, time taken to close wound, subject and surgeon satisfaction with device and wound closure, cosmetic outcome at 90 days, and complication rates. Results: Use of both devices resulted in effective wound closure with similar high levels of cosmesis subject and surgeon satisfaction, with only minor complications reported. There was no statistically significant difference between the devices for all the parameters studied, with the exception that the Liquiband device was found to significantly reduce the amount of time required for closure. Conclusion: As the two devices appear substantially equivalent in terms of key surgeon and patient variables, product cost should be the primary determinant in selection of the tissue glue device.