Comparison of anti-inflammatory dose doxycycline versus doxycycline 100 mg in the treatment of rosacea.

摘要

Rosacea is a chronic inflammatory dermatosis, but the exact etiology of rosacea remains unknown. It has been described as a result of "a disparate assortment of stimuli acting in concert on a genetically susceptible host" with a constitutional diathesis Among the many investigations into its patho-physiology, much interest has been focused on the role of the collagen-degrading matrix metalloproteinases (MMPs) and proteases that are involved in many aspects of tissue remodeling and local tissue inflammation. New research findings suggest that an upregulation of local inflammatory mediators play a key role in the pathophysiology of this chronic disease.