首页> 外文期刊>Journal of drugs in dermatology: JDD >Improvement in Signs and Symptoms of Plaque Psoriasis After 1 Week of Treatment With Clobetasol Propionate 0.05% Spray
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Improvement in Signs and Symptoms of Plaque Psoriasis After 1 Week of Treatment With Clobetasol Propionate 0.05% Spray

机译:丙酸氯倍他索0.05%喷雾治疗1周后斑块状牛皮癣的体征和症状改善

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摘要

Clobetasol propionate 0.05% spray (CPS) is a topical, super-high-potent corticosteroid indicated for the treatment of moderate to severe plaque psoriasis. Two pivotal trials of CPS investigated the efficacy and safety of treatment in subjects with moderate to severe plaque psoriasis. Overall disease severity (ODS), erythema, plaque elevation, scaling, and pruritus were assessed on a 5-point scale of 0 (clear) to 4 (severe/very severe). Overall disease severity treatment success was defined as achieving a score of <2 at week 2 and a score of <1 at week 4. Treatment success for all other parameters was defined as achieving a score of <1 at all time points. Based on Cochran-Mantel-Haenszel analysis, treatment success was achieved in the CPS group in both studies compared with vehicle after 2 weeks, but not after 1 week. Only subjects who achieved treatment success were considered for analysis. Thus, subjects who did not meet the criteria for treatment success were not examined for improvement. A post hoc analysis was conducted using all the data and the median as the measure of central tendency. It was shown that ODS, erythema, plaque elevation, scaling, and pruritus improved by 1 grade from baseline at week 1 in subjects given CPS. The data presented here suggest CPS is effective in improving the signs and symptoms of plaque psoriasis 1 week after initiating treatment.
机译:丙酸氯倍他索0.05%喷雾剂(CPS)是局部使用的超高效皮质类固醇,可用于治疗中度至重度斑块状牛皮癣。 CPS的两项关键试验研究了在中度至重度斑块状牛皮癣患者中治疗的有效性和安全性。总体疾病严重程度(ODS),红斑,斑块升高,结垢和瘙痒以5分制(从0(清晰)至4(严重/非常严重))进行评估。总体疾病严重程度的治疗成功定义为:第2周得分<2,第4周得分<1。所有其他参数的治疗成功定义为在所有时间点得分均<1。根据Cochran-Mantel-Haenszel分析,两项研究均显示CPS组的治疗成功与2周后的载体相比有所改善,但1周后没有。仅获得治疗成功的受试者才考虑进行分析。因此,不满足治疗成功标准的受试者将不进行检查以寻求改善。使用所有数据和中位数作为集中趋势的量度进行事后分析。结果显示,接受CPS的受试者在第1周时,ODS,红斑,斑块升高,结垢和瘙痒与基线相比改善了1级。此处提供的数据表明,CPS可在开始治疗1周后有效改善银屑病斑块的症状和体征。

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