Homocysteine, folic acid and vitamin B12 levels in females with severe acne vulgaris.

摘要

Acne is a pleomorphic disorder of the pilosebaceous unit, characterized by both inflammatory and non-inflammatory lesions. There are four primary pathogenic factors, which interact in a complex manner to produce acne lesions: fol-licular hyperkeratinization, excessive sebum production, hypercolonization of the duct by Propionibacterium acnes and direct or indirect inflammation. The fifth factor, now included in the pathogenesis, is matrix metalloproteinases (MMPs)(l).