Disposition index identifies defective beta-cell function in cystic fibrosis subjects with normal glucose tolerance

摘要

Background: In non-cystic fibrosis (CF) subjects, the disposition index (DI) is a strong predictor of the development of type 2 diabetes. CF subjects are at high risk of diabetes. We hypothesized that DI would be reduced in CF patients with normal glucose tolerance (NGT), indicating beta-cell dysfunction, and DI would worsen with progression from CF with NGT to CF-related diabetes (CFRD).