Synthesis, crystal structures, antioxidant activities, and DNA-binding studies of two silver( I) complexes with 1,3-bis ( 1-ethylbenzimidazol-2-yl)-2-thiapropane, and a, alpha,beta- unsaturated carboxylates

摘要

Two new ternary complexes of silver( I) with 1,3-bis(1-ethylbenzimidazol-2yl)-2- thiapropane (bebt) and two alpha,beta-unsaturated carboxylates, [Ag(bebt) ( crotonate)] ( 1) and [ Ag( bebt) 2]( o-coumarate) CH3CN 2C(2)H(5)OH ( 2), have been synthesized, and characterized by physicochemical and spectroscopic methods. Single-crystal X-ray diffraction revealed that the coordination environment of 1 can be described as trigonal planar, while 2 has a distorted tetrahedral geometry. Experimental studies of the DNA-binding properties indicated that the free ligand and both complexes bind to DNA via intercalation, and the order of the binding affinity is 1 > bebt > 2. Antioxidant activity experiments show that 2 possesses significant antioxidant activity against hydroxyl radicals, with more efficient hydroxy radical scavenging compared with mannitol and vitamin C.