Advanced drug and gene delivery systems based on functional biodegradable polycarbonates and copolymers

摘要

Biodegradable polymeric nanocarriers are one of the most promising systems for targeted and controlled drug and gene delivery. They have shownseveral unique advantages such as excellent biocompatibility, prolonged circulation time, passive tumor targeting via the enhanced permeability and retention (EPR) effect, and degradation in vivo into nontoxic products after completing their tasks. The current biodegradable drug and gene delivery systems exhibit, however, typically lowin vivo therapeutic efficacy, due to issues of lowloading capacity, inadequate